16th August 2010
Cascade Analysis mediator
Soluble mediators, interferons, cytokines and chemokines are expressed and developed in the framework of the cascade pro-inflammatory because of the NF-kB activation or IRF. Knowledge of specific receptors activated, the acti...
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01st December 2008
Despite intense interest and scrutiny focused on FOXP3 as a key protein & master transcription factor, isolating and enriching for viable FOXP3 positive cells remains a challenge. Although cell separation/staining via CD4+CD25+ selection is commonly use...
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01st December 2008
Folates play an important role in protein and nucleic acid biosynthesis and are particularly recognized for their roles in spinal canal and brain development during early pregnancy. FR4 is expressed at high levels on both natural and TGF-b induced Tregs. ...
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09th September 2008
Neuropilin-1 (Nrp-1) was recently identified as a possible surface marker for naturally occurring CD4+CD25+ regulatory T cells and is constitutively expressed on the cell irrespective of its activation status. Nrp-1 is a type 1 membrane protein with thre...
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09th September 2008
Tumor metastasis plays a key role in assessing treatment strategies and an important factor in determining patient prognosis. Not surprisingly, significant effort has been focused on elucidating the molecular basis behind tumor metastasis. This understa...
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16th April 2008
Toll-like receptor 10 (TLR10) often known as CD290 (cluster of differentiation 290), is the most recently identified human homolog of the Drosophila TOLL protein. Human TLR10 is an orphan member of the Toll-like receptor family that recognizes pathogen-as...
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16th April 2008
Toll-like receptor 9 (TLR9) often known as CD289 (cluster of differentiation 289), is a member of the Toll-like receptor family that recognizes pathogen-associated molecular pattern. TLR9 was first cloned and identified as a receptor for unmethylated CpG-...
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16th April 2008
Toll-like receptor 7 (TLR7), is an immune gene possessed by humans, other mammals and additionally in avian species playing a significant role in initiating antiviral immune responses. It belongs to the evolutionarily conserved Toll-like receptor family. ...
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16th April 2008
Toll-like receptor 4 (TLR4) often designated as CD284 (cluster of differentiation 284) is a class I transmembrane receptor belonging to the large homologous family of Toll like receptors. TLR4 expressed on the surface of immune system cells, is activated ...
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16th April 2008
Toll-like receptor 3 (TLR3) often designated as CD283 (cluster of differentiation 283) is a type I transmembrane receptor protein. It belongs to a family of evolutionary conserved innate immune recognition molecules and recognizes double-stranded RNA, a ...
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16th April 2008
Toll-like receptor 2 (TLR2), often designated as CD282 (cluster of differentiation 282) is a type I transmembrane protein belonging to the large homologous family of Toll like receptors. TLR2 acts as functional receptor for both Gram-positive and Gram-neg...
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16th April 2008
Toll-like receptor 1 (TLR1) often designated as CD281 (cluster of differentiation 281), a member of the Toll-like receptor family recognizes pathogen-associated molecular pattern with specificity for gram-positive bacteria. TLR1 is a 786-residue type I tr...
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07th March 2008
The p53 family member, p73, also known as tumor protein 73 (TP73) has been recently identified as a structural and functional homolog of the tumor suppressor protein p53. In accordance with its structural similarity, p73 functions in a manner analogous to...
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07th March 2008
The cytoskeleton is a network of fibers throughout the cell's cytoplasm that helps the cell maintain its shape and gives support to the cell. It is a cellular scaffolding or skeleton contained within the cytoplasm, present in both eukaryotes and prokaryot...
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